ABSTRACT
Coronavirus disease 2019 (COVID-19) has become an emerging pandemic, dominating the current outlook in pub- lic health. The typical clinical picture of COVID-19 encom- passes flu-like symptoms;including fever predominantly dry cough, dyspnea, asthenia, odynophagia, rhinorrhea, and headache. However, some patients may also develop cardiovascular manifestations, such as acute cardiac injury, heart failure, shock, and arrhythmias, among others. The pa- thogeny underlying this link has not been clarified;however, SARS-CoV-2 has been observed to penetrate cells via the angiotensin-converting enzyme 2, an important participant in the renin-angiotensin-aldosterone systemand the regulation of the cardiovascular system. The use of angiotensin-con- verting enzymeinhibitors and angiotensin II receptor antago- nistsmay cause upregulation of ACE2 and facilitate viral en- try. COVID-19 has also been related to various forms of co- agulopathy, with a tendency to favor pro-thrombotic states, increasing cardiovascular risk. The objective of this article is to explore the link between COVID-19 and cardiovascular disease, and its repercussions in clinical management.